Oxfendazole, the sulfoxide form of fenbendazole, is a broad spectrum benzimidazole anthelmintic. Oxfendazole acts by destroying the microtubular structure in the intestinal epithelium of helminths thus inhibiting the uptake of glycogen from the intestine of the parasite.

* Fenbendazolum [INN-Latin],

* 2-(Methoxycarbonylamino)-5-(phenylthio)benzimidazole,

* Methyl (5-(phenylthio)-1H-benzimidazol-2-yl)carbamate,

* [5-(Phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester,

* 2-Benzimidazolecarbamic acid, 5-(phenylthio)- methyl ester,

* AIDS-007898, * AIDS007898,

* Carbamic acid, (5-(phenylthio)-1H-benzimidazol-2-yl)-, methyl ester,

* Carbamic acid, [5-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester,

* CCRIS 7309, * CHEMBANK903, * EINECS 256-145-7, * F5396,

* Fenbendazol [INN-Spanish], *fenbendazole, *Fenbendazole [USAN:BAN:INN],

* HOE 881, *Hoe 881v, *HOE-881v,

* Methyl 5-(phenylsulfanyl)-1H-benzimidazol-2-ylcarbamate,

* Methyl 5-(phenylthio)-2-benzimidazolecarbamate, *ZINC00121553,

Fenbendazole is a broad spectrum benzimidazole anthelmintic, it is bound to the structural protein tubulin. This blocks polymerization of tubulin by inhibiting of celluar transport and energy metabolism, consequently causing damage to integrity and transport Pharmacodynamic Properties of the parasites?cells.

* Flubendazolum [INN-Latin],

* (5-(4-Fluorobenzoyl)-1H-benzimidazole-2-yl)carbamic acid methyl ester,

* Methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamate,

* Methyl N-(5-(p-fluorobenzoyl)-2-benzimidazolyl)carbamate,

* 2-Benzimidazolecarbamic acid, 5- (p-fluorobenzoyl)-, methyl ester,

* AIDS-084892, * AIDS084892,

* Carbamic acid, (5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl)-, methyl ester,

* Carbamic acid, [5- (4-fluorobenzoyl)-1H-benzimidazol-2-yl]-, methyl ester,

* CCRIS 4480, * EINECS 250-624-4,

* Flubendazol [INN-Spanish],

* Flubendazole [USAN:BAN:INN],

* Flubenol, * Flumoxal, * Flumoxane, * Fluvermal,

* N-{5-[(4-Fluorophenyl)carbonyl]benzimidazol-2-yl}methyloxymethanamide,

* NSC 313680, *NSC313680,

Flubendazole is a synthetic anthelmintic belonging to the benzimidazole carbamates which acts by inhibiting the microtubular assembly in absorptive cells of nematodes. It acts by binding to tubulin, the dimeric subunit protein of the microtubules. It inhibits microtubular assembly in absorptive cells: i.e. of intestinal cells of nematodes. This is shown by disappearance of cytoplasmic microtubules, accumulation of secretory granules in the cytoplasm due to a block in their transport, leading to an impaired coating of the cellular membrane and a decreased digestion and absorption of nutrients. Irreversible lytic degeneration of the cell, due to the accumulation of secretory substances (hydrolytic and proteolytic enzymes), results in the death of the parasite.

* Sodium N-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-o-tolyl)-2-hydroxy-3,5-diiodobenzamidate,

Closantel is a broad-spectrum antiparasitic agent used against several species and developmental stages of trematodes, nematodes and arthropods. The anti-trematode activity of closantel is mainly used against liver fluke. The anti-nematode and anti-arthropod activity is especially used against those species which feed on blood or plasma.

Closantel is an uncoupler of the mitochondrial oxidative phosphorylation resulting in inhibition of the ATP-synthesis. This induces a dramatic change in the energy metabolism which finally leads to the death of the parasite.